This applies to all RS items, not only inline spans and persits when disabling the Relative Style.
I think this setting is not intended to exist inside the Relative Styling panel and probably should be removed.
However, I think this could be an interesting feature but I’m not sure if it’s the right fit for the RS panel, as global block typography is class and not property based.
I want to apologise for prematurely closing the previous topic, though we do find it more convenient to manage bug reports by having separate issues in their respective reports.
I appreciate you opening this new one.
The team and I agree that removing the global block typography from the RS panel is the best course of action to prevent such issues from occurring again in the future.